Abstract
Long QT syndrome (LQTS) is a disease with a high risk of the dangerous arrhythmias. The article presents the results of electrocardiography (ECG), bicycle ergometry, and Holter monitoring (HM) in a sixteen-year-old girl with a history of syncope. The ECG showed prolongation of the corrected QT interval (QTc) till 522 ms with a late onset of the T wave. Genetic testing confirmed the LQT3 type (mutation in the SCN5A gene). During HM and bicycle ergometry, alternans of the QRS complex in combination with T wave alternans was first detected (AQRS/TA). A review of the literature on the problem was conducted.
AQRS/TA is a new ECG pattern in patients with LQT3, which most likely reflects increased arrhythmogenic vulnerability of the heart in these patients. However, this mention requires further study and observation.
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About the authors
- Leonid M. Makarov, Dr. Med. Sci., Professor, Head of Center for Syncope and Cardiac Arrthymias; ORCID
- Vera N. Komolyatova, Dr. Med. Sci., Pediatric Cardiologist; ORCID
- Elena V. Zaklyazminskaya, Dr. Med. Sci., Head of Medical Genetics Laboratory; ORCID
- Dmitriy A. Besportochnyy, Functional Diagnostician; ORCID
- Igor O. Islanov, Researcher; ORCID
- Irina I. Kiseleva, Cand. Med. Sci., Pediatric Cardiologist; ORCID
