Abstract
Clinicomorphological analysis of 554 case histories and autopsy protocols of neonates for 2000-2009 is carried out.
Common arterial duct (CAD) is found in 45% congenital heart defects. CAD pathomorphological signs show that
in the basis of its development there may be dysplastic and fibrotic changes of middle and external coats involving
proximal and distal portions. Important element in CAD morphogenesis is valvular neoplasms of cavernous
structure type and production of epithelioid smooth myocytes, myofibroblasts in the middle coat of the vessel. The
results obtained make it possible to update CAD pathogenesis in this cohort of infants.
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