Аннотация
Развитие медицины и фармакологии в рамках научно-технического прогресса представляет все больше возможностей по оказанию помощи пациентам в критическом состоянии, равно как и расширению арсенала врача–анестезиолога-реаниматолога в оптимизации терапии и поиске новых решений. Вазопрессин (AVP) – один из первых синтезированных пептидных гормонов, используемых для лечения несахарного диабета и желудочно-кишечных кровотечений в течение последних пяти десятилетий. Он был открыт Оливером и Шафером в 1895 г., когда они установили, что введение животным экстракта из гипофиза повышает артериальное давление, в то время как Фарини и Фельден описали его антидиуретические эффекты, успешно применяя его в лечении несахарного диабета. В 1954 г. Винсент де Виньо впервые синтезировал вазопрессин. Однако использование его для восстановления сосудистого тонуса при вазоплегическом синдроме впервые было описано только в 1997 г. С тех пор проведено множество исследований по определению эффективности, побочных эффектов, минимальных безопасных доз и критериев начала терапии.
Литература
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Об авторах
- Бачиева Асият Руслановна, анестезиолог-реаниматолог; ORCID
- Бекетовский Вячеслав Юрьевич, заведующий отделением; ORCID
- Иванова Алеся Геннадьевна, мл. науч. сотр., анестезиолог-реаниматолог; ORCID
- Маркелова Ксения Алексеевна, анестезиолог-реаниматолог; ORCID