Abstract
Objective. To analyze results of pulse oximetry screening in Tatarstan Republic in 2020–2022, estimate age on the day of correction of critical congenital heart defects (CCHD) in newborn with positive screening results and compare this data with the groups of prenatal and delayed diagnosis.
Material and methods. We analyzed cases of newborns with CCHD for 2020 and 2021. We divided patients into 3 groups: 1 – prenatal diagnosis (CCHD was diagnosed prenatally, 27 cases), 2 – screening group (CCHD was diagnosed after positive screening result, 15 cases), 3 – group of delayed diagnosis (CCHD was an accidental finding after discharge, 4 cases).
Results. Neonates from group 1 and 2 went through correction significantly earlier than patients from group 3 (p=0.009, p=0.01 respectively). Average age on the day of correction in groups 1, 2 and 3 was 5, 7 и 51,5 days respectively. No significant difference was found in in-hospital stay duration between groups.
Conclusion. Pulse oximetry screening in addition to prenatal ultrasound screening detects more than 30% additional patients with CCHD before discharge. Patients with positive screening results are going through surgical correction in earlier age.
References
- Sebelius K. Secretary of Health & Human Services letter to the Secretary’s Advisory Committee on Heritable Disorders in Newborns and Children (SACH-DNC). 2011. DOI: 10.1097/GIM.0b013e318210655d
- Kumar P. Universal pulse oximetry screening for early detection of critical congenital heart disease. Clin. Med. Insights Pediatr. 2016; 10: 35–41. DOI: 10.4137/CMPed. S33086
- De-Wahl Granelli A., Wennergren M., Sandberg K., Mellander M., Bejlum C., Inganäs L. et al. Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns. BMJ. 2009; 338: 3037. DOI: 10.1136/bmj.a3037
- Ewer A., Middleton L., Furmston A., Bhoyar A., Daniels J., Thangaratinam S. et al. PulseOx Study Group Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. Lancet. 2011; 378 (9793): 785–94. DOI: 10.1016/S0140-6736(11)60753-8
- Olney R.S., Ailes E.C., Sontag M.K. Detection of critical congenital heart defects: review of contributions from prenatal and newborn screening. Semin. Perinatol. 2015; 39 (3): 230–7. DOI: 10.1053/j.semperi.2015.03.007
- Plana M., Zamora J., Suresh G., Fernandez-Pineda L., Thangaratinam S., Ewer A. Pulse oximetry screening for critical congenital heart defects. Cochrane Database Syst. Rev. 2018; 3 (3): CD011912. DOI: 10.1002/14651858.CD011912.pub2
- Bogatchevskaia S.А., Kapitonenko N.А., Bogatchevskiy А.N. The epidemiological features of congenital heart diseases in the Russian Federation and the far Eastern Federal District for the last 10 years. Far Eastern Medical Journal. 2016; 1: 96–101 (in Russ.).
- Karpova A.L., Spivak E.M., Pykhantseva A.N., Bockeria E.L., Karpov N.Yu., Kondakova N.N., Tretyakova L.N. Pulse oximetry as a method of early neonatal screening for critical heart defects in children. Neonatology: News. Opinions. Training. 2015; 4: 68–72 (in Russ.).
- Gilboa S., Salemi J., Nembhard W., Fixler D., Correa A. Mortality resulting from congenital heart disease among children and adults in the United States, 1999 to 2006. Circulation. 2010; 122: 2254–63. DOI: 10.1161/CIRCULATIONAHA.110.947002
- Healthcare in Russia. 2021: Statistical collection/Rosstat. Moscow; 2021. https://rosstat.gov.ru/storage/mediabank/Zdravoohran-2021.pdf (accessed October 15, 2023) (in Russ.).
- Botto L., Correa A., Erickson J. Racial and temporal variations in the prevalence of heart defects. Pediatrics. 2001; 107 (3): E32. DOI: 10.1542/peds.107.3.e32
- Saperova Е.V., Vahlova I.V. Congenital heart diseases in children: incidence, risk factors, mortality. Current Pediatrics (Voprosy Sovremennoi Pediatrii). 2017; 16 (2): 126–33. DOI: 10.15690/vsp.v16i2.1713 (in Russ.).
- Zubko A.V., Sabgayda T.P. Child mortality from congenital heart diseases as a reflex of surgical treatment availability. Health Сare of the Russian Federation. 2019; 63 (6): 300–7 (in Russ.). DOI: 10.18821/0044-197X-2019-63-6-300-307
- Mozaffarian D., Benjamin E., Go A., Arnett D., Blaha M., Cushman M. et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016; 133 (4): е38–360. DOI: 10.1161/CIR.0000000000000350
- Pinto N., Keenan H., Minich L., Puchalski M., Heywood M., Botto L.D. Barriers to prenatal detection of congenital heart disease: a population-based study. Ultrasound Obstet Gynecol. 2012; 40 (4): 418–25. DOI: 10.1002/uog.10116
- Levy D., Pretorius D., Rothman A., Gonzales M., Rao C., Nunes M. et al. Improved prenatal detection of congenital heart disease in an integrated health care system. Pediatr. Cardiol. 2013; 34 (3): 670–9. DOI: 10.1007/s00246-012-0526-y
- Wik G., Jortveit J., Sitras V., Døhlen G., Rønnestad A., Holmstrøm H. et al. Severe congenital heart defects: incidence, causes and time trends of preoperative mortality in Norway. Archives of Disease in Childhood. 2020; 105: 738–43. DOI: 10.1136/archdischild-2019-317581
- Mat Bah M., Sapian M., Jamil M., Alias A., Zahari N. Survival and associated risk factors for mortality among infants with critical congenital heart disease in a developing country. Pediatr. Cardiol. 2018; 39: 1389–96. DOI: 10.1007/s00246-018-1908-6
- Lopes S.A.V.D.A., Guimarães I.C.B., Costa S.F.O., Acosta A.X., Sandes K.A., Mendes C.M.C. Mortality for critical congenital heart diseases and associated risk factors in newborns. A cohort study. Arq. Bras. Cardiol. 2018; 111 (5): 666–73. DOI: 10.5935/abc.20180175
About the authors
- Dinara I. Sadykova, Dr. Med. Sci., Professor, Chief of Chair; ORCID
- Dina R. Sabirova, Cand. Med. Sci., Associate Professor of Chair; ORCID
- Mirolim M. Mirzhalolov, Resident Physician, Pediatrician; ORCID