Aortic coarctation: etiology and pathogenesis, risk factors for reccurrence in the long- term postoperative period

Authors: Makarenko M.V., Tumanyan M.R.

Company: Bakoulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russian Federation

Cite as: Makarenko M.V., Tumanyan M.R. Aortic coarctation: etiology and pathogenesis, risk factors for reccurrence in the long-term postoperative period. Children’s Heart and Vascular Diseases. 2025; 22 (4): 255–264 (in Russ.). DOI: 10.24022/1810-0686-2025-22-4- 255-264

Received / Accepted: 28.05.2025 / 24.09.2025

Keywords: coarctation of the aorta arterial hypertension aortic recoarctation aortic aneurysm children

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Abstract

Aortic coarctation (CoA) is a fairly common congenital heart defect (CHD) (5–8% among all CHD). Currently, СoA is a well-studied heart defect, the methods of primary examination and surgical treatment of which have been developed. The evolution in the treatment of CoA over the past 3 decades has demonstrated improved survival. However, despite a fairly extensive treatment experience, there is still a large gap in the postoperative management of children, especially in the long-term period. There remains a high risk of developing cardiovascular diseases such as hypertension, restenosis and aortic aneurysm, heart failure, circulatory disorders and premature death. There are no developed recommendations for further examination and conservative treatment, and the issue of determining indications for repeated surgical correction remains a difficult problem. Thus, analyzing the literature and further studying this problem is relevant in the modern world to improve the quality and increase the life expectancy of patients. We conducted a literary review of scientific papers over the past 30 years using the resources of the PubMed and eLibrary search engines, using the keywords listed below.

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About the authors

Mariya V. Makarenko, Pediatric Cardiologist, ORCID
Margarita R. Tumanyan, Dr. Med. Sci., Head of Cardiac Surgery Department № 2; ORCID

Chief Editor

Konstantin V. Shatalov
MD, PhD, DSc, Professor
Bakoulev National Medical Research Center for Cardiovascular Surgery

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