Abstract
The aim of the study was to investigate the impact of intrauterine growth retardation (IUGR) on the outcomes of cardiac surgery under cardiopulmonary bypass in newborns with congenital heart defects (CHD).
Material and methods. A total of 128 newborns were examined. Inclusion criteria: correction of CHD with cardiopulmonary bypass. Patients with CHD were divided into groups depending on the presence/absence of intrauterine growth retardation. Maternal comorbid factors, preterm birth, birth weight, the most common CHDs associated with IUGR, complications and mortality were assessed in two groups.
Results. When comparing maternal factors between the group of newborns with CHD + IUGR and newborns with CHD, the mean age and arterial hypertension statistically significantly differed (p < 0.001; χ2 = 5.814 p = 0.016 respectively). The average weight of newborns also differed. When comparing preoperative clinical risk factors, the frequency of total parenteral nutrition and the number of cases of necrotic enterocolitis in the group of newborns with IUGR and CHD statistically significantly differed (χ2 = 19.053 p < 0.001; χ2 = 3.745 p = 0.050, respectively). Statistically significant differences in survival were revealed in the analyzed groups (Log-rang test p = 0.026).
Conclusion. Intrauterine growth retardation is a significant factor that can complicate the course and outcomes of cardiac surgery in the newborns with congenital heart defects. The combination of IUGR with prematurity and low birth weight represents a special risk group.
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About the authors
- Elena Z. Golukhova, Dr. Med. Sci., Professor, Academician of Russian Medical Sciences, Director; ORCID
- Irina Yu. Baryshnikova, Cand. Med. Sci., Head of Group of Ultrasound Innovative Solutions in Paediatrics; ORCID
- Rena M. Gasanova, Dr. Med. Sci., Head of Perinatal Center, Cardiologist, Ultrasound Specialist; ORCID
- Inessa E. Nefedova, Dr. Med. Sci., Head of Department; ORCID
- Vyacheslav Yu. Beketovskiy, Anesthesiologist & Intensivist, Head of the Department; ORCID
- Aleksey I. Kim, Dr. Med. Sci., Professor, Head of the Department; ORCID
