Abstract
Introduction. Necrotizing enterocolitis (NEC) is inflammatory disease occurring mainly in low birth-weight premature infants. According to different authors, the frequency of NEC is 4–28% among all newborns enrolled in the intensive care unit, or 0.3–2.4 case per 1000 newborns. A separate cohort from the bulk of children with realized necrotizing enterocolitis is patients with congenital heart diseases (CHD). As known, NEC realizes 10–100 times more often in children with CHD than in children without heart defects. The risk of it is 3.3–11, and their prognosis is worse than for children without CHD.
Objective: Analysis of management for patients with transposition of the great arteries, complicated by the development necrotizing enterocolitis.
Material and methods. In Bakoulev National Medical Research Center in period from 2007 to 2016 revealed 42 children with transposition of the great arteries (TGA), complicated by the severe course of necrotizing enterocolitis. This study included children with simple TGA (28 children), TGA in combination with a ventricular septal defect (13 children), and TGA with aortic coarctation (1 child)
Results. As the result of the treatment at the preoperative stage, the clinical and laboratory signs of NEC were stopped on the average after 3–6 days, what allowed to perform the next stage of surgical treatment. Thus, with the early detection and timely initiation of therapy for necrotizing enterocolitis in the preoperative period, we got a positive effect in the treatment of NEC in 68.2% (15 of 22 children with NEC realized before the surgical correction of CHD).
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About the authors
- Victoria P. Doktorova, Junior Researcher, ORCID
- Nino T. Siriya, Junior Researcher, ORCID
- Svetlana A. Zubkova, Junior Researcher, ORCID
- Elena G. Levchenko, Cand. Med. Sc., Senior Researcher, ORCID
- Aleksey G. Anderson Cand. Med. Sc., Senior Researcher, ORCID
