Abstract
Introduction. In the late postoperative period after mitral valve prosthesis, children and adolescents may develop complications such as prosthesis dysfunction due to the development of pannus, mismatch in the size of the prosthesis with the parameters of the child’s physical development, less often – prosthetic thrombosis.
Objective: To study the long-term results of mitral valve prosthetics in congenital heart diseases performed in childhood and adolescence.
Material and methods. The results of 273 mitral valve prosthesis surgeries in children and adolescents performed at the NCSSK in 1997–2017 are analyzed. Age at the time of surgery ranged from 1 month to 18 years (median – 3.5 (1.5 and 9.5) years).
Results. The time after surgery ranged from 1 to 18 years, an average of 6.1 ± 3.9 years. Re-prosthetics of the mitral valve was necessary in 99 (36.3%) of these patients. Prosthesis dysfunction due to pannus formation was noted in 44 (16.1%) cases, due to prosthesis thrombosis – in 7 (2.6%), due to prosthesis fistula – in 4 (1.5%), due to infective endocarditis – in 4 (1.5%), due to separation of the prosthesis – in 1 (0.4%) case. The mismatch between the size of the prosthesis and the parameters of the child’s physical development was noted in 37 (13.6%) cases. Cardiac arrhythmia requiring repeated surgical interventions were reported in 10 (3.7%) patients.
Conclusion. Repeated surgical interventions in most cases were associated with the occurrence of prosthesis dysfunction and prosthesis size mismatch with the patient's physical development parameters.
References
- Alsoufi B., Manlhiot C., Al-Ahmadi M., McCrindle B.W., Kalloghlian A., Siblini G. et al. Outcomes and associated risk factors for mitral valve replacement in children. Eur. J. Cardiothorac. Surg. 2011; 139: 1189–96. DOI: 10.1016/j.ejcts.2010.12.060
- Rafii D.Y., Davies R.D., Carroll S.J. et al. Age less than two years is not a risk factor for mortality after mitral valve replacement in children. Ann. Thorac. Surg. 2011; 91: 1228–34. DOI: 10.1016/j.athoracsur.2010.11.058
- Tierney E.S.S., Pigula F.A., Berul C.I. et al. Mitral valve replacement in infants and children 5 years of age or younger: Evolution in practice and outcome over three decades with a focus on supra-annular prosthesis implantation. J. Thorac. Cardiovasc. Surg. 2008; 136: 954–61. DOI: 10.1016/j.jtcvs.2007.12.076
- Ibezim C., Sarvestani A.L., Knight J.H., Qayum O., Alshami N., Turk E. et al. Outcomes of mechanical mitral valve replacement in children. Ann. Thorac. Surg. 2018; 26. PII: S0003-4975(18)31321-3. DOI: 10.1016/j.athoracsur. 2018.07.069
- Sawan E.B., Brink J., Soquet J., Liava'A M., Brizard C.P., Konstantinov I.E. et al. The ordeal of left atrioventricular valve replacement in children under 1 year of age. Interact. Cardiovasc. Thorac. Surg. 2017; 25 (2): 317–22. DOI: 10.1093/icvts/ivx114
- Beierlein W., Becker V., Yates R., Tsang V., Elliott M., de Leval M. et al. Long-term follow-up after mitral valve replacement in childhood: poor event-free survival in the young child. Eur. J. Cardiothorac. Surg. 2007; 31: 860–5.
- Ermolenko M.L. Prevention of complications after prosthetic mitral valve, performed in childhood and adolescence. Children’s Heart and Vascular Diseases. 2017; 14 (4): 223–8 (in Russ.).
- Bockeria L.A., Podzolkov V.P., Chiaurely M.R., Samsonov V.B., Sabirov B.N., Danilov T.Yu. Fifteen-year experience of heart valve replacement in infants. Russian Journal of Thoracic and Cardiovascular Surgery. 2013; 5: 13–8 (in Russ.).
- 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease. A Report of the American College of Cardiology/American Heart Association. J. Am. Coll. Cardiol. 2014; 63: 57–185
About the authors
- Marina L. Ermolenko, Dr. Med. Sc., Head of Department, ORCID
- Ol'ga I. Medvedeva, Dr. Med. Sc., Leading Researcher,
- Mariya N. Nevedrova, Cand. Med. Sc., Researcher, ORCID
- Timur Yu. Danilov, Dr. Med. Sc., Leading Researcher, ORCID
- Viktor B. Samsonov, Dr. Med. Sc., Leading Researcher, ORCID
- Dmitriy V. Kovalev, Dr. Med. Sc., Leading Researcher, ORCID
- Vera I. Dontsova, Cand. Med. Sc., Ultrasonic Diagnostics Physician, ORCID
- Viktoriya V. Plakhova, Dr. Med. Sc., Ultrasonic Diagnostics Physician, ORCID