Abstract
Introduction. A previously clinical trial of cardiac magnetic resonance (CMR) software 4D-flow in patients with congenital heart disease
demonstrated advantage of the program for comprehensive study blood flow.We sought to validate this software for quantification
of blood flow and flow distribution in patients with single-ventricle physiology (SVP).
Material and methods. 30 patients with SVP and bidirectional cavopulmonary connection underwent CMR (age 1 7 . 2 ± 8 . 6 years)
using new software 4D-flow. Quantitative analysis of blood volume and blood peak velocity were performed in the aorta, superior
and inferior vena cava (SVC and IVC), left and right pulmonary arteries (LPA and RPA). Distribution and direction of blood flow was
analyzed on maps vectors, particles and stream. Statistical analysis was performed using the software «Statistica».
Results. Reliable statistical difference was obtained only in the blood volume and velocity flow between SVC and IVC (p < 0.001).
Quantitative data were clearly displayed in the color maps. In the groups with and without added SVC statistical difference of blood
flow in LPA and RPA is not received, in spite of a correlation between the velocities in RPA and added SVC. According to the results
of correlation analysis blood flow in LPA and RPA depended on performance in various vessels.
Conclusion. 4D-flow allows retrospectively in vivo study in detail indicators of blood flow and geometry. Using the software in patients
with SVP at different stages of correction in conjunction with simulation hemodynamics and operations before a procedure, assessment of predictors of adverse outcome will help shape an optimal surgical strategy with clinical and economic benefit.
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